Kromozom 10, toplamda 22 çift olan otozomal insan kromozomlarından onuncusudur. İnsanlarda normalde bir çift halinde bulunur. 135 milyon baz çiftine ve toplam hücre DNA`sının %4 ya da %4,5`ine sahiptir. Kromozom 10, muhtemelen 800 ile 1,200 arasında gen içermektedir.
Genler
Kromozom 10 üzerinde bulunan genlerden bazıları:- CDH23: cadherin-like 23
- EGR2: early growth response 2 (Krox-20 homolog, Drosophila)
- ERCC6: excision repair cross-complementing rodent repair deficiency, complementation group 6
- FGFR2: fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
- PCBD1: 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
- PCDH15: protocadherin 15
- PTEN: phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
- RET: ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
- UROS: uroporphyrinogen III synthase (congenital erythropoietic porphyria)
Hastalıklar
Kromozom 10 üzerinde bulunan genlerle ilgili olan hastalıkların bazıları:- Apert syndrome
- Beare-Stevenson cutis gyrata syndrome
- Charcot-Marie-Tooth disease
- Charcot-Marie-Tooth disease, type 1
- Charcot-Marie-Tooth disease, type 4
- Cockayne syndrome
- congenital erythropoietic porphyria
- Cowden syndrome
- Crouzon syndrome
- Jackson-Weiss syndrome
- multiple endocrine neoplasia type 2
- nonsyndromic deafness
- nonsyndromic deafness, autosomal recessive
- Pfeiffer syndrome
- porphyria
- tetrahydrobiopterin deficiency
- Usher syndrome
- Usher syndrome type I
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